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Potassium salts of penicillin excessive endogenous potassium load increased production haemolysis rhabdomyolysis extensive burns tumor lysis syndrome intense physical activity trauma especially crush injuries and ischaemia redistribution shift from intracellular to extracellular fluid acidosis metabolic or respiratory insulin deficiency drugs succinylcholine beta-blockers digoxin acute intoxication or overdose hyperkalemic familial periodic paralysis diminished potassium excretion decreased excretion decreased glomerular filtration rate eg, acute or end-stage chronic renal failure decreased mineral corticoid activity defect in tubular secretion eg, renal tubular acidosis ii and iv drugs eg, nsaids, cyclosporine, potassium-sparing diuretics, ace inhibitors pseudohyperkalemia factitious haemolysis in laboratory tube most common thrombocytosis leukocytosis venepuncture technique e.
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